Project Report on COLCHICINE AND THIOCOLCHICINE [EIRI-1705]

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Project Report on COLCHICINE AND THIOCOLCHICINE [EIRI-1705] Price And Quantity

Minimum Order Quantity 1 Piece
Price 35000 INR/Piece

Project Report on COLCHICINE AND THIOCOLCHICINE [EIRI-1705] Trade Information

Supply Ability 1 Piece Per Day
Delivery Time 2-3 Days
Main Domestic Market All India

Product Description

Project Report on COLCHICINE AND THIOCOLCHICINE [EIRI-1705]

Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron"). Adverse effects are primarily gastrointestinal upset at high doses. In addition to gout, colchicine is used to treat familial editerranean fever, pericarditis, and Behçet's disease. The plant source of colchicine, the autumn crocus (Colchicum autumnale), was described for treatment of rheumatism and swelling in the Ebers Papyrus (ca. 1500 B.C.), an Egyptian medical papyrus. Colchicum extract was first described as a treatment for gout in De Materia Medica by Pedanius Dioscorides, in the first century AD. Use of the bulb-like corms of Colchicum to treat gout probably dates to ca. 550 AD, as the "hermodactyl" recommended by Alexander of Tralles. Colchicum corms were used by the Persian physician Avicenna,were recommended by Ambroise Pare in the sixteenth century, and appeared in the London Pharmacopoeia of 1618. Colchicum plants were brought to America by Benjamin Franklin, who suffered from gout himself and had written humorous doggerel about the disease during his stint as envoy to France. Colchicine was first isolated in 1820 by the French chemists P.S. Pelletier and J.B.Caventou. In 1833, P.L. Geiger purified an active ingredient, which he named colchicine. The determination of colchicine's structure required decades, although in 1945 Michael Dewar made an important contribution when he suggested that, among the molecule's three rings, two were 7-member rings. Its pain-relieving and anti-inflammatory effects for gout were linked to its ability to bind with tubulin. Oral colchicine had been used for many years as an unapproved drug with no prescribing information, dosage recommendations, or drug interaction warnings approved by the U.S. Food and Drug Administration (FDA).

COST ESTIMATION

Plant Capacity                        4 Kgs./day
Land & Building (1 Acre)        Rs. 2.35 Cr
Plant & Machinery                   Rs. 1.15 Cr
W.C. for 1 Month                    Rs. 2.22 Cr
Total Capital Investment        Rs. 6.09 Cr
Rate of Return                       25%
Break Even Point                    51%

Note: ITI can modify the Capacity and Project Cost based on your requirement.

Contents of the Project Reports

Introduction
Uses and Applications
Properties
Market Position
Present Manufacturers
Detailed Process of Manufacture
Formulations
B.I.S. Specifications
Process Flow Sheet Diagram, Plant Layout,
Cost Economics with Profitability Analysis
Capacity
Land & Building Requirements with Rates
List & Details of Plant and Machinery with their Costs
Raw Materials Details/List and Costs
Power & Water Requirements
Labour/Staff Requirements
Utilities and Overheads
Total Capital Investment
Turnover
Cost of Production
Break Even Point
Profitability
Land Man Ratio
Suppliers of Plant & Machineries and Raw Materials
Cash Flow Statement
Repayment Schedule
Interest Chart
Depreciation Chart
Projected Balance Sheet for 5 Years etc.